In an era of rapid technological advancements and shifting geopolitical landscapes, space agencies are looking to find ways to balance innovation with long-term strategic planning to ensure mission success, supply chain resilience, and sustained economic growth. This panel will bring together CEOs of leading space agencies to explore how enhanced global cooperation, policy alignment, and emerging technologies can optimise missions, strengthen industry partnerships, and drive sustainable expansion in the space sector. Discussions will focus on how agencies are leveraging data, AI, and automation to improve mission efficiency and reliability while ensuring continuity in funding, policy, and workforce development despite economic and political fluctuations. As the industry faces increasing demand for satellite communications and the UK looks to strengthen its position, securing robust and resilient supply chains has become a critical priority. Leaders will share insights into reducing dependencies, fostering international partnerships, and mitigating risks in critical space infrastructure. The session will also examine how space agencies can create an environment that enables commercial space companies to thrive, ensuring that national and new emerging space strategies align with the evolving needs of the global space economy. By fostering collaboration between governments, private industry, and research institutions, this discussion will highlight pathways to a more interconnected, resilient, and sustainable space ecosystem that drives both innovation and long-term business growth.